Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

The Turkish Journal of Ear Nose and Throat
Volume:28 Issue:2
Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Authors : Kazım BOZDEMİR, Arife SEZGİN, Ahmet AKKOZ, Özcan EREL, Mehmet Hakan KORKMAZ

Pages : 66-70

View : 44 | Download : 10

Publication Date : 2018-06-15

Article Type : Research Paper

Abstract :Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis. Patients and Methods: A total of 60 subjects 30 chronic sinusitis patients and 30 healthy volunteers were included in the study. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu. Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group. The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients had significantly lower native and thiol value than control group p<.001 and p=.001 . There was no significant difference between chronic sinusitis and control groups with respect to disulphide levels. Conclusion: Serum thiol and disulphide measurements can be used as a novel method for the reflection of inflammation for chronic rhinosinusitis patients.
Keywords : Chronic sinusitis, homesostasis, thiol disulphide

ORIGINAL ARTICLE URL

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.