Relationship of HBV-DNA levels with biochemical and microbiological markers in chronic hepatitis B patients

Authors : Ahmet Burak Gürpınar, Hacer Özlem Kalaycı
Pages : 473-480
Doi:10.18663/tjcl.1636298
View : 62 | Download : 153
Publication Date : 2026-01-01
Article Type : Research Paper
Abstract :Objective: HBV-DNA levels are used to diagnose Chronic Hepatitis B (CHB), determine the stage of infection, decide on treatment and determine the course of the disease. HBeAg is a marker of active viral replication and transcription, Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) are markers of liver inflammation. This study aims to investigate the relationship between HBV-DNA levels and age, biochemical and microbiological parameters in patients followed up with a preliminary diagnosis of CHB in our hospital. Materials and Methods: HBV-DNA, microbiological and biochemical parameters test results from blood samples of 264 patients followed up in our hospital with a preliminary diagnosis of CHB between May 2021 and May 2024 were retrospectively analyzed. HBV-DNA levels were divided into three groups as HBV-DNA Negative (Group 1), HBV-DNA 10-2000 IU/mL (Group 2) and HBV-DNA>2000 IU/mL (Group 3). Statistical analyses were performed with the MedCalc (version 20.009; Ostend, Belgium) statistical package program. Results: HBeAg positivity was significantly lower in HBV-DNA negative patients compared to patients with HBV-DNA 10-2000 IU/mL and HBV-DNA >2000 IU/mL and in patients with HBV-DNA 10-2000 IU/mL compared to patients with HBV-DNA >2000 IU/mL (p 2000 IU/mL compared to patients with HBV-DNA negative and HBV-DNA 10-2000 IU/mL. No statistically significant correlation was found between HBV-DNA levels and WBC, HGB, MCV, RDW, GGT, ALP, Total protein, albumin, PT, aPTT, INR values. Conclusion: A significant relationship was found between HBeAg and ALT, AST values and HBV-DNA levels in CHB patients. These parameters can be used together to diagnose CHB disease, establish the stage of infection, decide on treatment and determine the course of the disease.
Keywords : HBV-DNA, HBeAg, ALT, Kronik hepatit B

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