Evaluation of the Prognostic Importance of Gustave Roussy Immune Score in Hepatocellular Cancer Etiological Subtypes

Authors : İlknur Deliktaş Onur, Hatice Gülgün Fırat, Alper Türkel, Elif Sertesen Çamöz, Necla Demir, Fatih Yıldız
Pages : 570-575
Doi:10.18663/tjcl.1810106
View : 45 | Download : 119
Publication Date : 2026-01-01
Article Type : Research Paper
Abstract :Objective: The prognostic efficiencies of GRIm and HCC-GRIm scores in HCC have been determined in previous studies. However, there is no study evaluating them according to etiological subtypes in the literature yet. The aim of this study was to investigate the prognostic efficacy of GRIm (Gustave Roussy immune score) and HCC-GRIm score in HCC etiological subgroups. Methodology: The study was conducted on patients aged 18 years and older with unresectable/metastatic hepatocellular cancer (HCC) diagnosed between 2017 and 2023. GRIm and HCC-GRIm scores was calculated. The prognostic efficiencies of these scores were evaluated. Results: Sixty-seven (54%) of the patients had low GRIm scores, while 68(54.8%) had low HCC-GRIm scores. Median overall survival (OS) was 17.2 months in patients with low-viral GRIm scores, while median OS was 2.1 months in patients with high-viral GRIm scores. Median OS was 12.6 months in patients with low-nonviral GRIm scores. Median OS was 3.3 months in patients with high-nonviral GRIm scores (HR: 2.4(%95 CI 1.3-4.7) p<0.001). Conclusion: We found that GRIm score was prognostic in terms of OS in HCC. GRIm scores were higher in patients with viral etiology. However, when we evaluated the patients with low/high GRIM scores in terms of viral etiology/nonviral etiology, there was no significant difference in OS. We believe that the GRIm score may help clinicians in terms of prognosis in a difficult-to-manage disease such as HCC. Larger-scale studies investigating prognosis and treatment efficacies in etiological subtypes of HCC are needed.
Keywords : HCC-Grım skoru, GRIm skoru, HCC, HCC etyolojisi, HCC prognostik skor

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