Repolarisation Changes Associated with Serum Vitamin B12 Levels : Evaluation with Frontal QRS-T Angle

Authors : Fulya Avcı Demır, Gülsüm Bingöl, Akif Arslan, Meltem Demır, Ozge Ozden Kayhan, Serkan Ünlü

Pages : 637-643

Doi:10.18663/tjcl.1837555

View : 27 | Download : 137

Publication Date : 2026-01-01

Article Type : Research Paper

Abstract :Introduction: Vitamin B12 deficiency may influence cardiac autonomic function and ventricular repolarization. The frontal QRS-T angle is a novel and useful electrocardiographic parameter that reflects the relationship between ventricular depolarisation and repolarisation. The aim of this study was to evaluate the association between serum vitamin B12 levels and the frontal QRS-T angle in asymptomatic individuals. Method: The current retrospective study comprised 92 adults who underwent a standard 12-lead ECG and serum vitamin B12 testing on the same day. Participants were divided into two groups according to their vitamin B12 levels (Group 1 was defined as abnormal having a level of less than 300 pg/mL, while Group 2 was defined as normal having a level of 300 pg/mL or more). The patient\\\'s clinical characteristics, laboratory findings and ECG parameters were recorded. The frontal QRS-T angle was calculated automatically using the QRS and T axes provided by the ECG device. Results: The average age of participants was 46.1 (±12.2) years, and 51.9% of participants were female (p < 0.001). Individuals with low vitamin B12 concentrations exhibited a wider frontal QRS-T angle. It was determined that vitamin B12 level is an independent predictive factor for the frontal QRS-T angle. Conclusion: The frontal QRS-T angle may serve as a useful parameter for evaluating electrical changes and susceptibility to ventricular arrhythmias in individuals with vitamin B12 deficiency.
Keywords : elektrokardiyografi, frontal QRS-t açısı, repolarizasyon, vitamin B12

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