Association between second trimester maternal hypothyroidism and congenital heart diseases in fetuses: a retrospective study

Authors : Bekir Yukcu, Mehmet Albayrak

Pages : 322-329

Doi:10.18663/tjcl.1613893

View : 41 | Download : 25

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Aim: This study aimed to investigate the association between second-trimester maternal hypothyroidism and congenital heart diseases (CHDs) in fetuses. Material and Methods: This retrospective study was conducted at Obstetrics and Pediatrics Training and Research Hospital between June 2022 and December 2024. The patient group comprised mothers of children diagnosed with major CHDs, while the control group included mothers of children without CHDs or with minor anomalies not requiring intervention. Maternal thyroid status was determined by second-trimester TSH levels: >4.0 mIU/mL was classified as hypothyroid, while 0.2–4.0 mIU/mL was considered euthyroid. Statistical analyses, including ROC analysis, regression analysis, Chi-square test, Fisher\\\'s exact test, and Mann-Whitney U test, were performed using SPSS 25, with p 0.05). Conclusion: The study suggests a potential association between maternal hypothyroidism and fetal CHD.
Keywords : Maternal hipotiroidizm, konjenital kalp hastalığı, fetal ekokardiyografi, tiroid fonksiyonu, ikinci trimester

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