EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES

Authors : Çiğdem AYDIN ACAR, Suray PEHLİVANOĞLU, Mehmet KÖK, Gizem YILMAZ

Pages : 70-76

View : 36 | Download : 8

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds. Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences. Netrin-1 is a potential metabolic biomarker that has been associated with diabetes. Previous studies are scarce and have yielded contrasting results on serum netrin-1 levels in diabetes. The aim of this study was to investigate the correlation between serum netrin-1 levels and prediabetes. Methods: Sixty nine participants with prediabetes and 35 healthy controls were included in this study. Serum netrin-1 levels were determined using the Enzyme Linked Immunosorbent Assay insert ignore into journalissuearticles values(ELISA); method. Correlation analysis were done to assess the relationship between serum netrin-1 levels and biochemical parameters. Results: Serum netrin-1 levels were significantly decreased in the prediabetes group compared to the healthy control group insert ignore into journalissuearticles values(P<0.0001);. A significant negative correlation was observed between serum netrin-1 levels and age, hemoglobin A1c insert ignore into journalissuearticles values(HbA1c);, sedimantation, fasting blood glucose insert ignore into journalissuearticles values(FBG); and C-reactive protein insert ignore into journalissuearticles values(CRP); insert ignore into journalissuearticles values(r = -0.2738, 0.2886, r = -0.3180; P<0.01, r = -0.3439 and r = -0.3987; P<0.01, respectively. Conclusion: Serum netrin-1 significantly negative-correlated with prediabetes and also with FBG and HbA1c. These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.
Keywords : Netrin 1, Prediabetes, Biomarker

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