Evaluation of the efficacy of two different Helicobacter pylori eradication regimens at a secondary public health care center

Authors : Ferit ÇELİK, Ali ŞENKAYA

Pages : 32-38

Doi:10.56150/tjhsl.1246441

View : 29 | Download : 10

Publication Date : 2023-03-28

Article Type : Research Paper

Abstract :Objective: Helicobacter pylori insert ignore into journalissuearticles values(H. pylori); is a bacterium that infects more than half of the world\`s population and is defined as a class 1 carcinogen by the World Health Organization. The aim of this study is to compare the efficacy of treatments in patients with H. pylori positivity who were treated with a modified sequential treatment regimen containing levofloxacin or a bismuth-based quadruple treatment regimen in a secondary state hospital. Method: This study includes retrospective analysis of 167 patients who received and tolerated H. pylori eradication therapy between April 2021 and April 2022. The patients included in the study were divided into two groups according to the treatment regimen they received. Patients given a modified sequential treatment regimen containing levofloxacin insert ignore into journalissuearticles values(amoxicillin 1 g 2x1, pantoprazole 40 mg 2x1 for 7 days, followed by pantoprazole 40 mg 2x1 for 7 days, metronidazole 500 mg 3x1, levofloxacin 500 mg 1x1); Group 1 and the patients who were given bismuth-based quadruple therapy insert ignore into journalissuearticles values(14 days pantoprazole 40 mg 2x1, bismuth subsalicylate 262 mg 2x2, metronidazole 500 mg 3x1 and tetracycline 500 mg 4x1); were determined as Group 2. Results: A total of 14 patients insert ignore into journalissuearticles values(one in group 1 and 13 in group 2); could not tolerate H.pylori treatment, and eradication was achieved in 83 insert ignore into journalissuearticles values(90.2%); in group 1 and 70 insert ignore into journalissuearticles values(93.3%); in group 2 of 167 patients who completed the treatment. There was no statistically significant difference in eradication success rates in both treatment protocols insert ignore into journalissuearticles values(p=.470);. There was no significant difference between the treatment groups in terms of age, gender, indications for endoscopy, endoscopic diagnoses, pathological findings, and eradication indications. Conclusion: Considering the eradication success rates found in our study, it supports that the modified sequential treatment regimen containing levofloxacin may be an alternative to bismuth-based treatment in the first-line treatment in our country, or a second-line treatment in patients who cannot tolerate bismuth-based treatment. However, further studies on modified sequential therapy containing levofloxacin are needed.
Keywords : Bizmut, eradikasyon, Helicobakter pylori, levofloksasin

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