The correlation of tumor markers, neutrophil/lymphocyte ratio and FDG PET/CT measures in pancreatic cancer

Authors : Merve HAFIZOĞLU, Reyhan KOROGLU, Hacer DEMİR, Erhan BOZKURT, Emre HAFIZOĞLU

Pages : 95-101

Doi:10.46310/tjim.839545

View : 28 | Download : 14

Publication Date : 2021-07-29

Article Type : Research Paper

Abstract :Objective:This review will outline the correlation of tumor markers and NLR insert ignore into journalissuearticles values(Neutrophil/lymphocyte ratio); with measures such as MTV insert ignore into journalissuearticles values(mean total volume);, TLG insert ignore into journalissuearticles values(total lesion glycolysis);, and SUV insert ignore into journalissuearticles values(standart uptake value); in 18F FDG PET/CT in pancreatic carcinoma with the goal of selection of appropriate treatment modality and decrease rates of treatment failure and recurrences in pancreatic carcinoma by using tumor markers. In this way, we can predict the results of imaging modalities, using easy lab technics such as NLR and tm markers. Methods:45 patients that new diagnosed pancreatic cancer were included in the study. Diagnosis were confirmed by cytology. Their tumor marker levels insert ignore into journalissuearticles values(CA 19.9, CEA and AFP);, NLR and PET/CT measurements insert ignore into journalissuearticles values(SUVmax, SUVmean, TLG, MTV); were obtained. Patients that already diagnosed, followed up or treated by oncology department, were excluded. Results:When tumor markers were compared with PET/CT measurements insert ignore into journalissuearticles values(SUVmax, SUVmean, TLG, MTV and tumor size); there were no significant difference between them. Also, total uptake values of organs insert ignore into journalissuearticles values(liver, spleen, pancreas); were not related with tm marker levels. However, there were positive significant correlation between tumor size and SUVmax, SUVmean, TLG insert ignore into journalissuearticles values(p=0.02 r = 0.347, p=0.022 r = 0.340, p=0.008 r =0.392);. Conclusions:Tumor markers may help diagnosing or managing of pancreatic malignities, but we cannot predict PET/CT results according to tumor marker levels. So, tumor markers must be used as an adjunctive method for diagnosing malignities. They cannot be major determiner for malignities. Diagnosing and following up malignities should be supported by other laboratory technics and imaging methods.
Keywords : CA 19 9, CEA, AFP, SUVMAX, MTV, TLG