Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome

Authors : Özen ÖZ GÜL, Soner CANDER

Pages : 47-54

Doi:10.46310/tjim.1070164

View : 55 | Download : 11

Publication Date : 2022-04-01

Article Type : Research Paper

Abstract :Objective: In this study we aimed to evaluate the correlations between dehydroepiandrosterone sulfate-total testosterone insert ignore into journalissuearticles values(DHEAS/TT); ratio and insulin resistance, glycemic and lipid parameters. Methods: A total of 35 patients with polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS); and 34 healthy volunteers were included in the study. Anthropometric, clinical, biochemical, lipid and glycemic measurements were performed according to routine standards. Patients’ demographic, clinical, anthropometric, biochemical, glycemic, lipid and hormonal parameters were measured and recorded. DHEAS/TT ratio was calculated in all patients. DHEAS/TT ratio and metabolic parameters were compared between the PCOS and control groups. Results: There were significant differences between the PCOS and control groups in terms of fasting blood glucose, total cholesterol, high density lipoprotein cholesterol insert ignore into journalissuearticles values(HDL-c);, low density lipoprotein cholesterol insert ignore into journalissuearticles values(LDL-c);, triglycerides, insulin and homeostatic model assessment-Insulin resistance insert ignore into journalissuearticles values(HOMA-IR); values insert ignore into journalissuearticles values(for all, p<0.05);. Androstenedione and DHEAS/TT values were statistically significantly higher in the PCOS group. Pearson’s correlation analysis revealed no statistically significant correlation between DHEAS/TT ratio and body mass index insert ignore into journalissuearticles values(BMI);, HOMA-IR and lipid profile. Conclusion: In PCOS patients, glycemic and lipid parameters, HOMA-IR and DHEAS levels were significantly higher compared to the control subjects. In addition, the DHEAS/TT ratio was also significantly higher at limit in the PCOS group. However, no correlations were observed between DHEAS/TT ratio, BMI, glycemic and lipid parameters, suggesting that DHEAS/TT ratio is not an appropriate method to be used in prediction of metabolic status in patients with PCOS.
Keywords : Polycystic ovary syndrome, lipid profile, dehydroepiandrosterone sulfate testosterone, insulin resistance, body mass index

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