Evaluation of Patients Performed with Saline Infusion Test with a Pre-Diagnosis of Primary Hyperaldosteronism

Authors : Coşkun ATEŞ, Gül ADA, Filiz MERCAN SARIDAŞ, Ensar AYDEMİR, Erhan HOCAOĞLU, Özen ÖZ GÜL, Soner CANDER, Canan ERSOY, Erdinç ERTÜRK

Pages : 29-33

Doi:10.46310/tjim.1072050

View : 20 | Download : 9

Publication Date : 2022-04-01

Article Type : Research Paper

Abstract :Background: Primary hyperaldosteronism insert ignore into journalissuearticles values(PHA); is a primarily treatable cause of arterial hypertension characterized by low plasma renin and high aldosterone levels. The prevalence of secondary hypertension as a common endocrine cause is 5-13%. The plasma aldosterone/renin ratio insert ignore into journalissuearticles values(ARR); is the best available method for PHA screening. One or more confirmatory tests may be required to confirm or exclude patients` diagnoses. One frequently used confirmatory test is the saline infusion test insert ignore into journalissuearticles values(SİT);. We aimed to screen the patients who underwent SİT with the preliminary diagnosis of PHA and to compare the results of the patients diagnosed with essential hypertension insert ignore into journalissuearticles values(EH); and PHA. Material and Methods: Seventy-seven patients with a history of drug-resistant hypertension or unexplained spontaneous or diuretic-induced hypokalemia or adrenal incidentaloma, or a family history of early-onset hypertension or cerebrovascular accident at a young age insert ignore into journalissuearticles values( 0.05);. Basal plasma aldosterone insert ignore into journalissuearticles values(p 0.05);. The mean sodium value was significantly higher than the IHA insert ignore into journalissuearticles values(p <0.05);. Conclusion: Our study determined that the saline infusion test could be used to confirm the diagnosis of primary hyperaldosteronism. Its use alone was not sufficient in the differential diagnosis of aldosterone-synthesizing adenoma and idiopathic hyperaldosteronism.
Keywords : primary hyperaldosteronism, saline infusion test, essential hypertension, secondary hypertension, endocrine hypertension