Electroanalytical Analysis of Guaifenesin from Pharmaceuticals on Boron Doped Diamond Electrode

Authors : Fatma AĞIN, Gökçe ÖZTÜRK, Dilek KUL

Pages : 88-93

Doi:10.51435/turkjac.1136876

View : 14 | Download : 8

Publication Date : 2022-12-29

Article Type : Research Paper

Abstract :The expectorant drug guaifenesin insert ignore into journalissuearticles values(GFN); electroanalytical analysis was performed on boron doped diamond electrode insert ignore into journalissuearticles values(BDDE); by cyclic voltammetry insert ignore into journalissuearticles values(CV);, differential pulse voltammetry insert ignore into journalissuearticles values(DPV); and square wave voltammetry insert ignore into journalissuearticles values(SWV); methods. The results of CV studies indicate that the reaction mechanism of GFN in the oxidation direction on the BDDE is irreversible and diffusion controlled. The linearity ranges are 0.400 ˗ 100 µM and 0.800 ˗ 100 µM for DPV and SWV methods, respectively. Limit of detection insert ignore into journalissuearticles values(LOD); values are obtained as 1.47 nM for DPV and 2.92 nM for SWV. Quantitative analysis of GFN from the pharmaceuticals was performed with fully validated DPV and SWV methods without any pre-separation. The sensitive methods with good recovery, high precision and accuracy have been developed for the electroanalytical analysis of GFN.
Keywords : Boron doped diamond electrode, guaifenesin, voltammetry