Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.

Authors : Zehra CAN, Elif AYAZOGLU DEMİR, Zeynep AKAR, Yakup KARA, Betül GIDIK

Pages : 1-10

Doi:10.51435/turkjac.1246389

View : 73 | Download : 27

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :The study aims to investigated the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhbition and cytotoxic effects of two different of Artemisia spp. insert ignore into journalissuearticles values(Artemisia dracunculus L. and Artemisia dracunculoides Pursh); cultivated in Turkey organically, for the first time. Total phenolic, total flavonoid contents of the plants determined spectrophotometrically while antioxidant activity DPPH, CUPRAC, and FRAP was determined using colorimetric method. And also acetylcholinesterase enzyme inhibition activity and anti-cancer activity in-vitro aganist human melanoma insert ignore into journalissuearticles values(VMM917, CRL-3232);, lung carcinoma insert ignore into journalissuearticles values(A549, CCL-185); and, normal human fibroblast insert ignore into journalissuearticles values(hGF, PCS-201-018); cells were studied. Total phenolic insert ignore into journalissuearticles values(225-324 mgGAE/g sample); and total flavonoid contents insert ignore into journalissuearticles values(0.066-0.085 mgQAE/g sample);, antioxidant activity insert ignore into journalissuearticles values(DPPH insert ignore into journalissuearticles values(1.371-1.655 mg/mL);, CUPRAC insert ignore into journalissuearticles values(0.246-0.344 µM CTEAC); and FRAP insert ignore into journalissuearticles values(462.133-726.661 µM CTEAC););. A. dracunculus and A. dracunculoides extracts inhibited 40.09±0.65%, and 39.48±3.68% of acetylcholinesterase activity. It was determined that demonstrated the selective effect of A. dracunculus and A. dracunculoides on the cytotoxicity of A549 and hGF cells.
Keywords : Artemisia dracunculus, Artemisia dracunculoides, acetylcholinesterase, lung carcinoma, human melanoma

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