Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder

Authors : Ajda MUTLU MIHÇIOĞLU, Tayfun KARA

Pages : 98-106

View : 17 | Download : 13

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objectives: Methylphenidate insert ignore into journalissuearticles values(MPH); and Atomoxetine insert ignore into journalissuearticles values(ATX); are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder insert ignore into journalissuearticles values(ADHD);. Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions. Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate insert ignore into journalissuearticles values(OROS-MPH);, 46 using extended-release methylphenidate insert ignore into journalissuearticles values(ER-MPH);, and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography insert ignore into journalissuearticles values(ECG);, transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging insert ignore into journalissuearticles values(TDI);. Results: Statistically significant differences were observed in terms of A wave velocity insert ignore into journalissuearticles values(p=0,002);, E/A insert ignore into journalissuearticles values(p<0,001);, and E’ septal insert ignore into journalissuearticles values(p=0,002); between the groups. Children using ATX had higher A wave velocity than OROS-MPH users and controls insert ignore into journalissuearticles values(p<0.001, p=0.007, respectively); and lower E/A than OROS-MPH users and controls insert ignore into journalissuearticles values(p<0.001, for both);. Children using ER-MPH and ATX had lower E’ septal values compared to the control group insert ignore into journalissuearticles values(p<0.001, p=0.002, respectively);. Heart rate is higher in ATX users than in the control group insert ignore into journalissuearticles values(p=0,002);. Systolic blood pressure was lower in the ER-MPH and ATX group compared to the control group insert ignore into journalissuearticles values(p=0.001, for both);. Conclusion: ATX medication exhibited impaired myocardial relaxation findings more than long acting-MPH medications. ER-MPH medication stated negative findings in diastolic cardiac functions more than OROS-MPH. As a result ADHD medications can produce negative effects on cardiac functions.
Keywords : metilfenidat, atomoksetin, doku Doppler görüntüleme, dikkat eksikliği ve hiperaktivite bozukluğu