Glutamin Enema Might Have Helped Reversing İntestinal Mucosal İnjury Among Diarrheic Calves: Trophic Aminoacid For ‘Microbiota-Gut-Brain Axis’

Authors : Deniz Alıç Ural

Pages : 171-176

Doi:10.53493/avrasyasbd.1711822

View : 40 | Download : 44

Publication Date : 2025-09-30

Article Type : Research Paper

Abstract :Introduction: Glutamine (Gln) has been denoted as an effectual nutritional supplementation for improving the gastrointestinal barrier function of animals. Aim: In the present study evaluating the efficacy of Gln on intestinal morphology, as detected by Diamine oxidase (dAo), a valuable marker for detecting gastrointestinal toxicity and intestinal mucosal injury, among diarrheic calves. Materials and Methods: In a total of 20 calves with diarrhea, with unknown etiology, were enrolled at this study. Following physical examination performed by board certified veterinary surgeons (who were not involved other than technical intervention), rapid diagnostic test kits were applied without any responsible etiological agent detected, a total of 0.9 ml blood was withdrawn from each calf. Sandwich ELISA by use of commercially available bovine dAo test kits were deemed available. Glutamine (Gut-cumin I Liquid Sol.) was given via rectal route as 15 mg/kg for 7 consequtive days. Results: Mean± SE dAo (ng/mL) analysis were deemed available at days 0 (start of trial) and primary end point (day 7), presented 9.12±2.46 vs. 28.19±3.18 (p<0,01), respectively. Conclusion: It should not be unwise to draw suggestion that a trophic aminoacid, glutamine, might have helped reversing intestinal mucosal injury among diarrheic calves as detected by dAo levels. Highlights: Glutamine may be a repair molecule and feed additive in intestinal damage.
Keywords : bağırsak, diamin oksidaz, glutamin, hasar, ishal

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