Detection of some phenolic content of Grimmia ovalis (Hedw.) Lindb. and investigation of its antimicrobial activity with molecular docking technique

Authors : Zafer Çambay, Harun Uslu, Bünyamin Göktaş, Kevser Özdemir Bayçinar, Ümmügülsüm Tükenmez Emre, Mevlüt Alataş

Pages : 52-58

Doi:10.26672/anatolianbryology.1705249

View : 52 | Download : 43

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :This study aims to investigate the phenolic compounds and pharmacological potential of Grimmia ovalis (Hedw.) Lindb. to understand their bioactive potential and to pioneer future research. It also aims to be one of the first studies on G. ovalis\\\'s in silico bioactivity. HPLC analysis revealed the detection of some phenolic compounds in G. ovalis extract. The study revealed the in silico antimicrobial potential of some phenolic compounds. We calculated that compounds of 2,5-dihydroxybenzoic acid and caffeic acid would inhibit Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) at micromolar levels. We concluded that they interacted with residues crucial for antimicrobial activity on the mentioned macromolecule.
Keywords : Briyofit, Antimikrobiyal Aktivite, Fenolik Bileşikler, Moleküler Doklama

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