Iterated bootstrap procedure in individual bioequivalence

Authors : Ufuk BEYAZTAS

Pages : 583-594

Doi:10.31801/cfsuasmas.438407

View : 17 | Download : 8

Publication Date : 2019-02-01

Article Type : Research Paper

Abstract :In this paper, we propose an iterating principle in the bootstrap method to assess the individual bioequivalence under 2×4 randomized crossover design. The finite sample properties of the proposed algorithm are illustrated by an extensive simulation study and a real-world example. Our findings reveal that the proposed idea have better performance than the classical percentile bootstrap confidence limits.
Keywords : Bioequivalence, bootstrap, hypothesis testing