Monitoring Blood Pressure Variability via Chaotic Global Metrics using Local Field Potential Oscillations

Authors : David GARNER, Shouyan WANG, Ashley RAGHU, Vitor VALENTİ, Tipu AZİZ, Alexander GREEN

Pages : 65-77

Doi:10.51537/chaos.1262839

View : 203 | Download : 152

Publication Date : 2023-07-31

Article Type : Research Paper

Abstract :The intention was to associate blood pressure insert ignore into journalissuearticles values(BP); variability insert ignore into journalissuearticles values(BPV); measurements to Local field potentials insert ignore into journalissuearticles values(LFPs);. Thus, assessing how LFPs can co-vary with BPV to permit implantable brain devices insert ignore into journalissuearticles values(via LFPs); to control output. Elevated BPV is a considerable cardiovascular disease risk factor. Often patients are resistant to pharmacotherapies. An alternative treatment is Deep Brain Stimulation insert ignore into journalissuearticles values(DBS);. Mathematical techniques based on nonlinear dynamics assessed their correlation of BPV chaotic global metrics to LFPs. Chaos Forward Parameter insert ignore into journalissuearticles values(CFP6); was computed for LFPs, at three electrode depths in the mid-brain and sensory thalamus. Mean, root mean square of the successive differences insert ignore into journalissuearticles values(RMSSD); and the chaotic global metrics insert ignore into journalissuearticles values(CFP1 to CFP7); were computed for the BP signal. The right ventroposterolateral insert ignore into journalissuearticles values(RVPL); nucleus provided a substantial correlation via CFP6 for BP with R-squared up to approximately 79% by means of LFP gamma oscillations. Investigation of BPV via LFPs as a proxy marker might allow therapies to be attuned in a closed-loop system. Whilst all patients were chronic pain patients the chaotic global relationship should be unperturbed. LFPs correlation does not unconditionally predict its causation. There is no certainty DBS in these locations would be therapeutic but can be used as an assessment tool.
Keywords : Chaotic Global Metrics, spectral Multi Taper Method, Blood Pressure Variability, Local Field Potentials, Deep Brain Stimulation

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