Usage and Results of Levosimendan in Ischemic Mitral Valve Surgery

Authors : Murat B RABUS, Mehmet DEDEMOGLU, Ozge ALTAS, Davut CEKMECELİOGLU, Mehmet AKSUT, Rahmi ZEYBEK

Pages : 443-447

Doi:10.33808/clinexphealthsci.605644

View : 27 | Download : 15

Publication Date : 2020-12-30

Article Type : Research Paper

Abstract :Objective: Large number of comprehensive studies has been carried out on levosimendan. There are many studies on its use, especially in  cardiac dysfunction, ischemic cardiac surgery, and heart transplantation surgery. But, there are limited number of studies regarding its use in  mitral valve interventions and ischemic mitral dysfunction combined with coronary artery by-pass surgery insert ignore into journalissuearticles values(CABG);. We aimed to investigate the  efficacy of levosimendan usage on patients undergone combined coronary artery by-pass grafting and mitral valve surgery because of ischemic  mitral dysfunction. Methods: Subsequent patients, who have undergone concurrent CABG and mitral valve repair surgery by a single surgery team, were  retrospectively examined. 36 patients were divided into 2 groups; Group 1 insert ignore into journalissuearticles values(levosimendan therapy group, n=15); and Group 2 insert ignore into journalissuearticles values(n=21);. Results: There was no statistically significant difference between the groups in terms of preoperative characteristics, echocardiographic data of  the patients and preoperative medication. Inotrope therapy was required for 12 patients in Group 1, which was statistically higher than Group  2 insert ignore into journalissuearticles values(n=5, p=0.001);. Moreover, IABP following LCOS utilized six and two patients in group 1 and 2 with a statistically significant difference insert ignore into journalissuearticles values(p=0.03);,  espectively. Conclusion: We recommend using levosimendan on selected patients for its several beneficial effects. However, we do not satisfied with the  treatment because the pathology of all patients was not related to ischemia, more to the alteration of ventricle anatomy with deterioration of  diameters.
Keywords : levosimendan, ischemic, mitral valve, mitral repair