The Determination of IL-6 rs1800795 Polymorphism Distribution in Turkish National Cross-Country Skiing Athletes Sub-groups Created Referring to the 1km CCSTAs

Authors : Derya KAZANCI, Tolga POLAT, Canan SERCAN DOĞAN, Beste TACAL ASLAN, Şehkar OKTAY, Muhammed Fatih BİLİCİ, Ömer KAYNAR, Başak Funda EKEN, Korkut ULUCAN

Pages : 782-786

Doi:10.33808/clinexphealthsci.904524

View : 35 | Download : 24

Publication Date : 2021-10-26

Article Type : Research Paper

Abstract :Objective: Interleukin-6 insert ignore into journalissuearticles values(IL-6); is an effective and functional protein with a cytokine structure. IL-6 is effective in the immune system like a pro/anti-inflammatory response, and muscle tissue hypertrophy and repair. Our study aimed to investigate the IL-6 rs1800795 polymorphism distribution in Turkish National Cross-Country Skiing Athletes and to determine the advantageous genotype for endurance performance. Methods: 34 athletes within 3 groups; General insert ignore into journalissuearticles values(Group-1);, Women insert ignore into journalissuearticles values(Group-2);, and Men insert ignore into journalissuearticles values(Group-3); were enrolled to the study. Also each groups were divided into sub-groups according to their “1-kilometer cross-country average skiing-times insert ignore into journalissuearticles values(1 km-CCSTAs);”. Blood samples were used for DNA isolation and genotyping were completed by real time- PCR. Results: The groups` 1 km-CCSTAs were 188.7 ± 22.4, 212.3 ± 17.8, and 177.4 ± 14.1 seconds, respectively. We detected the genotypes as 17 GG insert ignore into journalissuearticles values(50%); and 17 GC insert ignore into journalissuearticles values(50%); in Group-1; 5 GG insert ignore into journalissuearticles values(45%); and 6 GC insert ignore into journalissuearticles values(55%); in Group-2; 12 GG insert ignore into journalissuearticles values(52%); and 11 GC insert ignore into journalissuearticles values(48%); in Group- 3. We detected no CC genotype in groups. Chi-square Fisher’s test was used for statistical analysis. Conclusion: An increased GC genotype ratio was detected in the faster sub-groups of each group compared to the slower sub-groups. But we obtained the significant genotype distribution only in Group-3 insert ignore into journalissuearticles values(p <0.0001);. Also, an increased C-allele frequency was detected in the faster sub-groups. However, the significant allele gene distribution was obtained only in Group-3 insert ignore into journalissuearticles values(p=0.0002);. According to our results, we can speculate that the GC genotype is more advantageous than the GG genotype in Cross-Country Skiing Athletes.
Keywords : IL 6 genotypes, cross country skiing, endurance, athletic performance, sports genetics