The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Authors : Ayhan TANYELİ, Fazile Nur EKİNCİ AKDEMİR, Ersen ERASLAN, Mustafa Can GÜLER, Saime ÖZBEK ŞEBİN, Selim COMAKLI, İlhami GÜLÇİN

Pages : 134-140

Doi:10.33808/clinexphealthsci.864015

View : 24 | Download : 12

Publication Date : 2022-03-30

Article Type : Research Paper

Abstract :Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture insert ignore into journalissuearticles values(CLP); model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.
Keywords : Cecal ligation puncture, sinapic acid, lung, kidney, rat