The Role of p-Coumaric Acid on Reproductive and Remote Organ Damages Created by Adnexal Torsion/Detorsion: Biochemical and Immunohistochemical A Study

Authors : Ayhan TANYELİ, Fazile Nur EKİNCİ AKDEMİR, Ersen ERASLAN, Mustafa Can GÜLER, Tuncer NACAR, Selim ÇOMAKLI, İlhami GÜLÇİN

Pages : 1005-1012

Doi:10.33808/clinexphealthsci.1036428

View : 23 | Download : 19

Publication Date : 2022-12-30

Article Type : Research Paper

Abstract :Objective: We planned to search the effects of p-coumaric acid on ovary and lung injuries formed via bilateral adnexal torsion detorsion insert ignore into journalissuearticles values(T/D); in experimental rat model. Methods: 24 female, Sprague-Dawley rats were sorted out as 3 groups. Design of the groups was performed as sham insert ignore into journalissuearticles values(group I); and T/D insert ignore into journalissuearticles values(group II);, p-coumaric acid+T/D insert ignore into journalissuearticles values(group III); groups. Sham group; abdomen area was applied incision and repaired with no T/D model application. T/D group; 3 h of torsion phase completed and then 3 h of detorsion stage was established. P-coumaric acid+T/D group; p-coumaric acid was administered at the dose of 100 mg/kg for 15 days by oral gavage and then, T/D model was performed. Following detorsion phase, rats were sacrificed, lung and ovarian tissues were excised for biochemical and immunohistochemical evaluations. Results: When it is compared to group I, oxidant parameters elevated significantly in group II insert ignore into journalissuearticles values(p<0.05); while the activity of antioxidant enzymes and TAS level decreased. On the other side, antioxidant enzyme activity raised and oxidant parameter levels diminished in group III compared to group II insert ignore into journalissuearticles values(p<0.05);. Moreover, NF-kB, caspase 3 and LC3B protein expression levels increased in ovary and lung tissues of the group II. But NF-kB, caspase 3 and LC3B protein expression levels decreased in group III. Conclusion: As a consequence, p-coumaric acid acted a protective performance against ovary and lung injuries arising from adnexal T/D model in rats.
Keywords : p Coumaric Acid, Adnexal Torsion Detorsion, Ovary, Remote organ, Rat