Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia

Authors : Mehmet Ali TEMİZ

Pages : 129-136

Doi:10.33808/clinexphealthsci.1061083

View : 23 | Download : 10

Publication Date : 2023-03-28

Article Type : Research Paper

Abstract :Objective: Objective: Medicinal herbs offer natural remedies for various ailments because of their comprehensive effects. Scorzonera cinerea L. insert ignore into journalissuearticles values(Sc); is an edible wild plant and is used in traditional medicine against various diseases. The purpose of this study was to investigate the immune system effects of S. cinerea radical leaf extract in diabetic rats. Methods: The 5 groups were formed — Control, Diabetic, Sc-Dried, Sc-Frozen, and Acarbose. Adenosine deaminase insert ignore into journalissuearticles values(ADA);, xanthine oxidase insert ignore into journalissuearticles values(XO);, and myeloperoxidase insert ignore into journalissuearticles values(MPO); activities in liver and kidney tissues were analyzed. Hematological parameters were also evaluated. Results: ADA, XO, and MPO activities in both tissues significantly increased in diabetic conditions. However, Sc treatments significantly decreased liver ADA, liver and kidney XO, and liver and kidney MPO activities. There was no significant change in red blood cell insert ignore into journalissuearticles values(RBC); parameters. Although platelet insert ignore into journalissuearticles values(PLT); count and MPV were raised in the diabetic group, these parameters were reduced with Sc-Dried and Sc-Frozen treatment. While lymphocyte insert ignore into journalissuearticles values(LYM%); significantly decreased in defense cells in the diabetic group, neutrophil insert ignore into journalissuearticles values(NEU%);, monocyte insert ignore into journalissuearticles values(MO%);, and eosinophil insert ignore into journalissuearticles values(EOS%); elevated. However, a significant decrease was observed in NEU% and EOS% with Sc treatment. Conclusion: S. cinerea treatment can exert a potential immunoregulatory effect in diabetes. Thus, S. cinerea can be considered as an adjuvant to augment immune system on diabetes.
Keywords : Adenosine deaminase, Hematology, Immunity, myeloperoxidase, Scorzonera cinerea, xanthine oxidase