Search, Look, and See Late Recognised Hypereosinophilic Syndrome with Deletion (4) (q12)

Authors : Nurhilal BUYUKKURT, Funda PEPEDİL TANRİKULU

Pages : 441-443

Doi:10.33808/clinexphealthsci.855710

View : 53 | Download : 93

Publication Date : 2023-06-15

Article Type : Other Papers

Abstract :The hypereosinophilic syndrome insert ignore into journalissuearticles values(HES); is a group of rare disorders characterized by persistently high peripheral blood eosinophiles insert ignore into journalissuearticles values(≥ 1.5x109/L);, and related signs or symptoms of organ involvement without secondary causes. Eosinophilia with recurrent genetic abnormalities insert ignore into journalissuearticles values(PDGFRA/B, FGFR1); comprises a minority of these patients. In this report, we aimed to point out a case with 4q12 deletion whose diagnosis and treatment were delayed for quite a while. The patient was followed for bronchial asthma for a long time and the recognition of hypereosinophilia yielded a suspicion for HES / Chronic eosinophilic leukemia insert ignore into journalissuearticles values(CEL);. During the initial part of his diagnostic evaluation, there was an unawareness of the cryptic deletion which was a target for tyrosine kinases. The symptoms resolved and complete cytogenetic response was achieved with 100 mg imatinib continuing for 57 months.
Keywords : Hypereosinophilic syndrome, del 4, q12, tyrosine kinase inhibitors