ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS

Authors : H H ZOOROB

Pages : 0-0

Doi:10.1501/Commub_0000000265

View : 30 | Download : 6

Publication Date : 1985-01-01

Article Type : Research Paper

Abstract :Reaction of benzaldehyde with optically active bromoacetic ester derivative I in a Refor* matzky reaction gives, after hydrolysis of the resulting ester, laevorotatory B-hydroxy-Bphenyl phenyl-propionic acid. Moreover, reaction of ethyi bromoacetate with acetophenone in the pre¬sence of zinc and 1,2:5,6-di-Odsopropylideno-a-D-glucofuranose insert ignore into journalissuearticles values(II); is accompanied by partial asymmetric synthesis as is shownby hydrolysis of the resulting ester to laevorotatory B-hydroxy -B-phenylbutyric acid.
Keywords : ASYMMETRIC, REFORMATZKY REACTION, p HYDROXY ACIDS

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