Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides

Authors : İsmail ASLAN, Ahmet Arif KURT

Pages : 49-53

Doi:10.38093/cupmap.737878

View : 16 | Download : 11

Publication Date : 2020-06-27

Article Type : Research Paper

Abstract :This research study was designed to investigate physicochemical properties of types of phytosome containing alcohol-free umckalin from Pelargonium sidoides .  Fourteen different phytosomal formulations were prepared by film method using P. sidoides in various types of phosphatidylcholine; Phospholipon 85 G insert ignore into journalissuearticles values(P 85 G); and phospholipon 100H insert ignore into journalissuearticles values(PL 100H);.  Physicochemical properties were measured by particle size and size distribution, zeta potential and polydispersity index of optimum 4-phytosomal formulation. Polarized light microscopy insert ignore into journalissuearticles values(PLM); techniques were employed for obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of phytosomes was performed by using PLM. The most suitable alcohol-free phytosome combination was chosen as PL 100H: DCP: CHOL insert ignore into journalissuearticles values(10: 1: 4); containing 1 % P.S insert ignore into journalissuearticles values(UP 4); because of its particle size and distribution insert ignore into journalissuearticles values(<1000 nm); and zeta potential insert ignore into journalissuearticles values(<-30 mV);. 
Keywords : Liposome, Phytosome, Umckalin, Pelargonium sidoides, Characterization, Alcohol free extract