Investigation of Genotoxic Mechanisms of Etofenprox: Cytotoxicity, Micronucleus and Comet Analyses

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Environmental Toxicology and Ecology
Cilt: 5 Sayı: 2
Investigation of Genotoxic Mechanisms of Etofenprox: Cytotoxicity, Micronucleus and Comet Analyses

Investigation of Genotoxic Mechanisms of Etofenprox: Cytotoxicity, Micronucleus and Comet Analyses

Pages : 72-81

View : 28 | Download : 29

Publication Date : 2025-10-13

Article Type : Research Paper

Abstract :Etofenprox is a synthetic pyrethroid pesticide widely used in agriculture, with significant ecotoxicological concern due to its potential for long-term persistence in the environment. This study aimed to evaluate the cytotoxic and genotoxic effects of etofenprox on Chinese hamster ovary (CHO) cells. Cytotoxicity was determined by measuring the cytokinesis-block proliferation index (CBPI) after exposure to various concentrations (1–800 µg/mL) of etofenprox. Genotoxicity was assessed using the micronucleus (MN) assay and alkaline comet assay. The results revealed significant reductions in CBPI, increases in MN frequency, and pronounced elevations in DNA damage parameters (tail length, % tail DNA, olive tail moment) at higher concentrations. These effects increased in a dose-dependent manner, particularly at concentrations ≥200 µg/mL, where the changes were statistically significant (p<0.05). The data indicate that at high doses, etofenprox may cause both clastogenic effects and DNA strand breaks. The findings suggest that, while the pesticide may pose a low risk at typical environmental exposure levels, high-dose exposure can induce adverse effects at cellular and genetic levels.
Keywords : Etofenprox, genotoksisite, sitotoksisite, mikronükleus testi, komet testi

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