Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity

Authors : Eda YİLDİZHAN, Burak Veli ÜLGER, Murat AKKUŞ, Ömer Faruk KATANALP, Ebru GÖKALP ÖZKORKMAZ, İbrahim YILDIZHAN

Pages : 400-5

Doi:10.37990/medr.1197782

View : 14 | Download : 8

Publication Date : 2023-05-15

Article Type : Research Paper

Abstract :Aim: Deltamethrin insert ignore into journalissuearticles values(DM); is an insecticide and is widely used around the world. Rosmarinic acid insert ignore into journalissuearticles values(RA); is found in herbs and spices in the Lamiaceae insert ignore into journalissuearticles values(mint); family and has antioxidant, antiinflammatory and antiapoptotic effects. We objective to examine the protecting efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. Material and Methods: In ours study we used 28 male rats. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral insert ignore into journalissuearticles values(p.o.); for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. Results: BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. TAS and TOS grades were higher in the DM group matched to the RA+DM group. The damage scores of the DM group were higher aacording as those of the RA+DM group. Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.
Keywords : Deltamethrin, rosmarinic acid, hepatotoxicity, nephrotoxicity