Expression of VEGF in Fallopian tubes in Ovarian Ischemia-Reperfusion

Authors : Veysel TOPRAK, Engin DEVECİ

Pages : 337-41

Doi:10.37990/medr.1240419

View : 13 | Download : 4

Publication Date : 2023-05-15

Article Type : Research Paper

Abstract :Aim: Our aim was to investigate expression level of VEGF in tuba uterine in ovarian ischemia-reperfusion insert ignore into journalissuearticles values(I/R); by immunohistochemical techniques. Material and Methods: 30 Sprague Dawley female rats were categorized into three groups. Sham group: The abdomen was opened and closed without any treatment. Ischemia insert ignore into journalissuearticles values(I); group: 1-hour ischemia was allowed to create ischemic injury. Ischemia-reperfusion insert ignore into journalissuearticles values(I/R); group: 1-hour ischemia and then 3-hour reperfusion was allowed to create I/R injury. Results: MDA and MPO levels were increased after ischemia and IR while GSH content was decreased. Histological scores of follicular degeneration, inflammation, hemorrhage were high in I and IR groups. Normal histology of tuba uterine was observed in sham group. In I and IR group, degenerated cilia, desquamative epithelial cells impaired basement membrane leukocytes infiltration, apoptotic nuclei, vascular dilatation, thrombosis and inflammation and adenoma were observed. VEGF expression was mainly in sham group. In I and IR group, endothelial cells, adenoma structures, vessels, macrophage and inflammatory leukocyte cells and fibroblast cells showed positive VEGF expression. Conclusion: IR damage affected inflammation and angiogenesis, changes in implantation.
Keywords : VEGF, ischemia reperfusion, fallopian tubes, histopathology