Epigenetic Effects of Social Stress and Epigenetic Inheritance

Authors : Halime Sena EKMEKCİ, Sümeyye MUFTAREVİÇ

Pages : 132-145

Doi:10.18863/pgy.1059315

View : 12 | Download : 9

Publication Date : 2023-03-31

Article Type : Review Paper

Abstract :Social events that cause stress can cause epigenetic changes on living things. The study of the effects of social events experienced by an individual on epigenetic marks on the genome has created the field of social epigenetics. Social epigenetics examines the effects of psychosocial stress factors such as poverty, war trauma and childhood abuse on epigenetic mechanisms. Epigenetic mechanisms alter chemical markers in the genome structure without changing the DNA sequence. Among these mechanisms, DNA methylation in particular may have different phenotypic effects in response to stressors that may occur in the psychosocial environment. Post-traumatic stress disorder is one of the most significant proofs of the effects of epigenetic expressions altered due to traumatic events on the phenotype. The field of epigenetic inheritance has shown that epigenetic changes triggered by environmental influences can, in some cases, be transmitted through generations. This field provides a better understanding of the basis of many psychological disorders. This review provides an overview of social epigenetics, PTSD, and epigenetic inheritance.
Keywords : Sosyal epigenetik, stres, DNA metilasyonu, travma sonrası stres bozukluğu, epigenetik kalıtım