Immunodeficiency In The Human Newborn

Authors : Öner ÖZDEMİR

Pages : 14-18

View : 15 | Download : 11

Publication Date : 2019-12-10

Article Type : Conference Paper

Abstract :Abstract The normal neonate’s immune system is anatomically intact, antigenically naive, and shows somewhat decreased role of a number of immunological pathways. Aside from anatomic characteristics insert ignore into journalissuearticles values(eg, thin skin and mucosal barriers); of newborn, weakened proinflammatory and T helper cell type 1 insert ignore into journalissuearticles values(Th1); cytokine release and lessened cell-mediated immunity predispose the neonate more susceptible to all types of infections. However, most of the newborn stand this period without sickness due to intact innate immunity with other adaptive defense mechanisms, and maternally transferred immunoglobulin G insert ignore into journalissuearticles values(IgG);. Besides unique immunity of the premature baby and normal newborn; risk factors, clinical features and laboratory evaluation of primary immunodeficiency diseases insert ignore into journalissuearticles values(PIDs); are told in this presentation. Moreover, most important PIDs of the newborn including antibody deficiencies, cellular/combined immunodeficiencies, phagocytic diseases, complemento-pathies and innate immune system disorders are briefly mentioned here as well.
Keywords : Immunodeficiency