Two Cases With Tyrosine Kinase 2 Deficiency :

Authors : Hülya VATANSEV

Pages : 568-571

View : 14 | Download : 8

Publication Date : 2019-12-10

Article Type : Conference Paper

Abstract :About a quarter of the word’s population is infected with Mycobacterium tuberculosis, but this bacterium causes tuberculosis in less than 10% of infected individuals. In the countries in wich tuberculosis is highly endemic, primary tuberculosis is particulary common in the children and adults. Clinical and epidemiological studies suggest that tuberculosis in humans has a strong genetic basis. Autosomal recessive insert ignore into journalissuearticles values(AR); complete interleukin-12 receptor β 1 insert ignore into journalissuearticles values(IL-12R β 1); and tyrosine kinase 2 insert ignore into journalissuearticles values(TYK2); deficiencies are the only two inborn errors of immunity reported to date to underlie primary tuberculosis in otherwise healthy patients in two or more kindreds insert ignore into journalissuearticles values(1,2);. Inherited IL-12R β 1 and TYK2 deficiencies impair both IL-12– and IL-23–dependent IFN-g immunity and are rare also causes of tuberculosis insert ignore into journalissuearticles values(3,4);.
Keywords : Two Cases