The Effect of Rosmarinic Acid Against Ovarian and Lung Injuries Induced by Ovarian Torsion Detorsion in Rats

Authors : Ayhan TANYELİ, Fazile Nur EKİNCİ AKDEMİR, Derya GÜZEL, Kardelen ERDOĞAN, Ersen ERASLAN, Gökhan BİLGİN, Mustafa Can GÜLER
Pages : 47-52
Doi:10.21765/pprjournal.1304994
View : 94 | Download : 54
Publication Date : 2023-07-31
Article Type : Research Paper
Abstract :Background: Here, we purposed to find out the effects of two different Rosmarinic acid insert ignore into journalissuearticles values(RA); doses against lung injury caused by ovarian ischemia-reperfusion. Materials and Methods: We planned the groups as sham, ovarian torsion detorsion insert ignore into journalissuearticles values(O/TD; 3hours torsion/3hours detorsion);, RA 40 mg/kg insert ignore into journalissuearticles values(40 mg/kg RA+O/TD);, and RA 80 mg/kg insert ignore into journalissuearticles values(80 mg/kg RA+O/TD); groups. Following the experimental procedure, we sacrificed the rats and then, collected the lung and ovarian tissues for biochemical evaluations. Result: Total oxidant status insert ignore into journalissuearticles values(TOS);, myeloperoxidase insert ignore into journalissuearticles values(MPO); activity, malondialdehyde insert ignore into journalissuearticles values(MDA); levels, and oxidative stress index insert ignore into journalissuearticles values(OSI); were elevated in the O/TD group compared to the sham group. These parameters declined due to low and high doses of RA administration. Total antioxidant status insert ignore into journalissuearticles values(TAS); level and superoxide dismutase insert ignore into journalissuearticles values(SOD); activity diminished in the O/TD group while increasing in RA treatment groups. However, the high dose of RA treatment group enhanced the antioxidant activity further and reduced the oxidant parameters compared to the low dose RA treatment group. Conclusion: In this study, RA treatment reduced O/TD-induced ovarian and lung injuries in the experimental animals.
Keywords : Rosmarinik asit, torsiyon detorsiyon, over, rat

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