The Effects of Quercetin and Hyperthermia on OVCAR-3 Cells

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Abant Tıp Dergisi
Volume:10 Issue:2
The Effects of Quercetin and Hyperthermia on OVCAR-3 Cells

The Effects of Quercetin and Hyperthermia on OVCAR-3 Cells

Authors : Özlem ÖZGÜR GÜRSOY, Canan VEJSELOVA SEZER, Ceren YILDIZ EREN, Hulusi Göktuğ GÜRER

Pages : 212-218

Doi:10.47493/abantmedj.881050

View : 83 | Download : 15

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Aim: the aim of this study is to exhibit the growth inhibitory effect of quercetin on the human ovarian epithelial carcinoma cells (OVCAR-3) and scrutinize the effect of hyperthermia. Materials and Methods: OVCAR-3 cells were exposed to different concentrations of quercetin and apoptotic changes were recorded with confocal microscopy and transmission electron microscopy. Also Annexin-V analysis and ROS measurement were analyzed. Cytotoxicity was tested on quercetin exposed OVCAR-3 cells with hyperthermia. Results: Quercetin have good anticancerous activities in vitro by inhibiting the proliferation of OVCAR-3 cells. The recorded IC50 value of quercetin was 122 μM for 48 hours. Hyperthermia didnot influence significantly on the growth inhibition of OVCAR-3 cells applied with quercetin. Conclusion: Our results demonstrated that quercetin could induce apoptosis in a time and concentration-dependent manner in OVCAR-3 cells.
Keywords : kuersetin, OVCAR 3 hücreleri, hipertermi

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