Effect of favipiravir use on INR, PT, aPTT tests of COVID-19 patients

Authors : Mehmet Ali GÜL, Nezahat KURT, Mustafa ÇAPRAZ, Alpaslan ÖZTÜRK

Pages : 14-20

Doi:10.55895/sshs.1213382

View : 32 | Download : 11

Publication Date : 2023-01-03

Article Type : Research Paper

Abstract :The 2019 coronavirus disease insert ignore into journalissuearticles values(COVID-19); has caused millions of cases worldwide. As the pandemic progresses, understanding the effects of this disease remains important. We aimed to examine the hematological effects of the disease. The research was carried out as a retrospective study, 50 patients using favipiravir and 50 patients not using favipiravir who had positive COVID-19 RT-PCR test in nasal and throat swabs were included in the study. INR, PTT, aPTT tests were evaluated on all patients. Results of patients using favipiravir; INR 1.3±0.2, PTinsert ignore into journalissuearticles values(s); 16.4±3.4, aPTTinsert ignore into journalissuearticles values(s); 40.7±10.1, while the results of patients who did not use favipiravir were INR 1,2±0.2, PTinsert ignore into journalissuearticles values(s); 14.6±2.5, aPTTinsert ignore into journalissuearticles values(s); was found 38.4±7.8. While PT and INR were found to significantly higher in patients using favipiravir insert ignore into journalissuearticles values(p<0.05);, the elevation in aPTT values was not significant. As a consequence, it was obtained that favipiravir prolongs the clotting time. In the light of these results, it is recommended to consider this in anticoagulant therapy used for treatment.
Keywords : COVID 19, favipiravir, INR, PT, aPTT