NON-CELIAC GLUTEN SENSITIVITY: A TRADITIONAL REVIEW

Authors : Cansu Memiç İnan, Ceren Şarahman Kahraman, Mustafa Çapraz

Pages : 86-94

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Publication Date : 2025-08-25

Article Type : Review Paper

Abstract :Non-celiac gluten sensitivity (NCGS) is a disorder characterized by gastrointestinal and extra-intestinal symptoms caused by the consumption of gluten-containing foods in individuals who do not have celiac disease or wheat allergy. The limited knowledge regarding NCGS has led to various challenges in diagnosis and disease management. Due to the lack of sensitive and reproducible biomarkers for diagnosis, current evidence on NCGS prevalence is primarily based on survey studies. Although it is believed that both innate and adaptive immune systems play a role in the pathogenesis of NCGS, this remains an area of uncertainty. A gluten-free diet is recommended as the best treatment method for symptom control in NCGS. However, the gluten-free diet may lead to deficiencies in certain macro and micronutrients, and thus should be followed under the supervision of a nutritionist and clinician. With the continuously evolving body of knowledge, significant progress has been made in understanding the perspective on NCGS. The aim of this review is to provide a comprehensive overview of the etiopathogenesis, clinical features, and treatment of NCGS considering the most recent data.
Keywords : Tanı, Epidemiyoloji, Glutensiz diyet, Non-çölyak gluten hassasiyeti

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