The effective ethanol rate against the toxicity of ethylene glycol

Authors : Faik GÖKALP

Pages : 20-26

Doi:10.33435/tcandtc.813939

View : 22 | Download : 15

Publication Date : 2021-06-15

Article Type : Research Paper

Abstract :Ethylene glycol insert ignore into journalissuearticles values(EG); is a toxic substance and EG metabolites cause metabolic acidosis. The major emphasis in this study is to get rid of the toxicity of EG before conversion to its metabolites. The interaction between ethylene glycol and ethanol has been studied using DFT insert ignore into journalissuearticles values(Density functional theory method);. In ethylene glycol metabolites in the blood; Glycolic acid is more stable and gloxal less stable. The interaction of ethylene glycol with ethanol has been considered for ethylene glycol metabolism. Thermodynamic values obtained from ethylene glycol metabolites and ethanol were also analyzed. According to the analyst results of ethanol and ethylene glycol ratios; The maximum effective point is very stable in the blood and its solubility is determined at this rate. It is very important to determine the most appropriate rate in the prevention of toxicity. This study is an important study in terms of the use of ethanol in the prevention of toxicity of EG, the first of its rates and in terms of preventing the loss of time and substance.
Keywords : Ethanol, density functional theory, ethylene glycol, glyoxal, blood