Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?

Authors : Handan SARAÇ, Ahmet DEMİRBAŞ, Burak TÜZÜN

Pages : 42-56

Doi:10.33435/tcandtc.1198612

View : 60 | Download : 135

Publication Date : 2023-09-03

Article Type : Research Paper

Abstract :Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.
Keywords : Zingiber officinale, SARS CoV 2, omicron, molecular docking, ADME T