Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

Authors : Duygu Bayir Garbioglu, Bülent Yildiz, Serap Işiksoy, Nazan Demir, Murat Dinçer
Pages : 344-349
Doi:10.29058/mjwbs.1354666
View : 75 | Download : 48
Publication Date : 2023-12-31
Article Type : Research Paper
Abstract :Aim: Although solid tumors are known to metastasize to the bone marrow, it is rare to be diagnosed with bone marrow involvement. In our study, we aimed to contribute to the literature by evaluating the treatment results and follow-up processes of different solid tumors metastatic to bone marrow in denovo. Material and Methods: We retrospectively analyzed 28 patients who underwent bone marrow biopsy with a prediagnosis of hematologic malignancy and were diagnosed with carcinoma metastasis. Clinicopathologic features, antitumor treatments, treatment-related hematologic toxicities and factors affecting survival were evaluated. Results: Of the 28 patients included in the study, 14 (50.0%) were female and 14 (50.0%) were male. The median age of the patients was 62 years (28-82). Eight patients (28.6%) were diagnosed with breast (28.6%), six with gastric (21.4%), four with lung (14.3%), two each with colon and prostate ca (7.1%), and the primary tumor site could not be determined in six patients (21.4%). Progression was observed in four (40.0%) of the 10 patients with the first series of treatment, three (30.0%) patients had stable response and three (30.0%) patients had partial response. The median progression-free survival time was 130 days (3-494 days) in patients who received first line treatment. The median overall survival time was 26 days (0-1183 days). Thrombocytopenia (p<0.05), hypofibrinogenemia (p<0.05), and poor performance score (p<0.05) were associated with lower survival. Conclusion: Solid tumor patients diagnosed with denovo bone marrow metastases have a very poor prognosis. Additional poor prognostic factors in these patients include thrombocytopenia, hypofibrinogenemia, poor performance status. Accurate and rapid diagnosis of the primary solid tumor through bone marrow biopsy can help establish an appropriate treatment approach focused on the primary carcinoma
Keywords : kemik iliği metastazı, solid tümörler, toksisite

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