Evaluation of Complete Blood Count in Chronic Lymphoid Leukemia Patients

Authors : Ayşe Dalyan, Sibel Bayıl Oguzkan, Mehmet Özaslan

Pages : 61-67

Doi:10.55549/zbs.1586463

View : 117 | Download : 112

Publication Date : 2025-01-13

Article Type : Research Paper

Abstract :Chronic Lymphoid Leukemia (CLL) is characterized by the uncontrolled proliferation of lymphocytes, usually in the elderly, which can lead to various hematological abnormalities in patients. Analysis of hematological parameters is very important for the diagnosis, prognosis, and monitoring of treatment response in CLL. This study aimed to compare the complete blood count (CBC) parameters of CLL patients with a healthy control group. The study included 50 patients diagnosed with CLL and 50 healthy controls without a history of cancer. CBC parameters (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, RDW, RDW-SD, PDW, PLT, MPV, PCT, NEU%, LYM%, MONO%, EOS%, BASO%, NEU#, LYM#, MONO#, EOS#, BASO#, NRBC#) of CLL patients and control group were statistically compared. According to the analysis results, no significant difference was found between MCV, RDW, RDW-SD, PDW, MPV, BASO%, NEU#, and EOS# values of the patient and control groups (p>0.05). However, WBC, RBC, HGB, HCT, LYM%, MONO%, LYM#, MONO#, BASO#, and NRBC# values of the patient group were significantly higher relative to the control group (p<0.05). MCH, MCHC, PLT, PCT, NEU%, and EOS% parameters were significantly higher in the control group relative to the patient group (p<0.05). As a result, significant differences were observed in some CBC parameters between patients and the control groups. Particularly, the significant difference observed in some parameters emphasizes that the hematological profile of CLL can be used in the diagnosis and monitoring processes. Our findings support
Keywords : CLL, Prognosis, CBC, Leukemia, Hematological parameters

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