In Utero Etanol Uygulamasının Sıçan Testis Morfolojisi Üzerine Etkileri

Authors : Yasemin Ersoy ÇANILLIOĞLU, Feriha ERCAN

Pages : 10-16

View : 35 | Download : 17

Publication Date : 2011-03-01

Article Type : Research Paper

Abstract :Aim: Ethanol causes testicular atrophy, loss in germ cells,decrease in sperm production, decrease in the radius of seminiferous tubule lines and decrease in the testicular weight. Ethanol use in pregnancy also causes teratogenic effects in fetus by degenerating reproductive functions both in males and females. The aim of this study is to examine the testicular changes in rats which are applied ethanol in utero. Method: 2 experimental groups were used: 1 Control group 2 Alcohol group. Alcohol group was given liquid containing 30% ethanol beginning from the 14th gestational day until birth. Testicular samples were obtained from 0, 15, 30 and 90-day-old offsprings of mother rats in experiment and control groups. Sections were administered routine paraffin method and stained with Masson’s trichrome for morphologic examination. Result: As in alcohol neonatal group some disorders in seminiferous tubules were observed, a degeneration in seminiferous tubules and decrease in spermatogenic cell series were observed related with the time. In alcohol neonatal and postnatal 15 days group mesenchymal tissue, in postnatal 30 days and 90 days groups the interstitiel tissue were observed to be more. Conclusion: As a result in utero ethanol administration cause severe degeneration in the spermatogenic cell series in the seminiferous tubules of the male offsprings. Related to this, in utero ethanol causes infertility by decreasing the number of cells in spermatogenic series and testicular atrophy in males.
Keywords : Ethanol, diffrentiation, infertility, morphology, testis