The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats

Authors : Taha CEYLANİ, Hikmet Taner TEKER

Pages : 242-246

Doi:10.17798/bitlisfen.1231238

View : 42 | Download : 18

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :In this study, the effects of TUDCA administration with a SCD probiotics for one week on locomotors activity and anxious behavior were investigated. Male Saprague-Dawley rats aged 24 months were used as the model organism. At the end of the application, open-field and elevated plus maze behavioral tests were performed on the rats. Although SCD probiotics were more effective on anxious behavior, the group in which they were administered together had a significantly greater effect on locomotor activity and anxious behavior. This study provides important evidence that combining SCD probiotics and TUDCA administration may be more beneficial to behavior.
Keywords : TUDCA, SCD probiotics, OF, EPM, Anxiety

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