Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate

Authors : Rukiye BORAN, Tuba BAYGAR, Nurdan SARAÇ, Semih AYRIKÇİL, Derviş YILMAZ, Aysel UĞUR

Pages : 99-104

Doi:10.30728/boron.1180847

View : 25 | Download : 17

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Boron containing compounds insert ignore into journalissuearticles values(BCGs); have recently been used for pharmaceutical applications. Zinc, an essential element, is known to be one of the most promising biodegradable metals. The present study was conducted to determine the wound healing properties of zinc borate with its antimicrobial, antifibrinolytic and enzyme inhibitory characteristics. In vitro scratch wound healing assay revealed that zinc borate at 0.01 µg/mL concentration stimulated the proliferation of 3T3 fibroblast cells after 24 h of scar formation. The highest enzyme inhibition was observed against collagenase at 1 mg/mL insert ignore into journalissuearticles values(81.5%);. Minimum inhibition concentration insert ignore into journalissuearticles values(MIC); values were determined as 1 mg/mL and 0.5 mg/mL against Candida albicans and Staphylococcus aureus, respectively. Zinc borate did not have any fibrinolytic activity at 1, 0.5 and 0.1 mg/mL concentrations. It can be suggested that zinc borate can be used effectively to improve the wound healing process and to prevent the possible wound infections.
Keywords : zinc borate, wound healing, enzyme inhibition, antimicrobial, antifibrinolytic