Effect of boric acid and quercetin combination on oxidative stress/ cognitive function in parkinson model

Authors : Elif YAVUZ, Güven ÇEVİK, Burcu ÇEVRELİ, Emel SERDAROĞLU KAŞIKÇI

Pages : 85-91

Doi:10.30728/boron.1215949

View : 48 | Download : 28

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Parkinson\`s disease insert ignore into journalissuearticles values(PD); is a one of the important neurodegenerative disorders that affect dopaminergic neurons in the brain. Quercetin is one of the most potent antioxidants among all flavonoids, with direct radical scavenging activities and induction of antioxidative enzymes. Studies have shown that boric acid is essential for the activity of brain functions. We also used 3-month-old Wistar-albino male rats in our study, the experimental groups were divided into 8 groups insert ignore into journalissuearticles values(n=7); and Glutathione insert ignore into journalissuearticles values(GSH); and Malondialdehyde insert ignore into journalissuearticles values(MDA); levels were determined manually in brain tissue samples. Also, Total Antioxidant Status insert ignore into journalissuearticles values(TAS); was determined using a commercial kit. Locomotor Activity and Object Recognition tests were applied to evaluate the cognitive functions of the rats. GraphPad Prism 9 version was used for statistical analysis. Values were statistically analyzed by one-way ANOVA, differences between groups were determined using Uncorrected Fisher\`s LSD tests. p < 0.05 was considered statistically significant. In our study, we think that BA will positively affect the oxidant-antioxidant balance by preventing the pathogenesis of PD.
Keywords : Parkinson, Rotenone, Boric acid, Quercetin, Oxidative stress