Boron as a protective agent in reducing paracetamol-induced testicular toxicity in rats: A biochemical perspective

Authors : Esra Aktas Senocak, Necati Utlu

Pages : 61-67

Doi:10.30728/boron.1595247

View : 76 | Download : 41

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :In the study, the protective effects of boron against paracetamol (PR)-induced toxicity in rat testicular tissue were investigated using various biochemical parameters. Rats were categorized into five groups and administered 50 and 100 mg/kg of boron (sodium pentaborate) orally for six days, followed by a single dosage of 1 g/kg of paracetamol to induce toxicity. Testicular tissues were assessed using ELISA and levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), cysteine-aspartic acid protease (Caspase-3), malondialdehyde (MDA), reduced glutathione (GSH), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) were assessed. A significant decrease in SOD, CAT, GPx activities and GSH levels and an increase in MDA levels were observed in the PR group. Boron (B) treatment was found to increase antioxidant levels while decreasing lipid peroxidation, inflammation and apoptosis markers in paracetamol-induced testicular toxicity (p<0.001). The study concluded that boron may be effective in alleviating paracetamol-induced testicular damage.
Keywords : bor, inflamasyon, oksidatif stres, parasetamol toksisitesi, testiküler hasar

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