EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi

Authors : Tuba ÇIFTÇI KÜSBECI, Serap ARGUN BARIŞ, Füsun YILDIZ, İlknur BAŞTIĞIT, Haşim BOYACI, Ahmet ILGAZ

Pages : 111-119

View : 14 | Download : 8

Publication Date : 2022-12-15

Article Type : Research Paper

Abstract :ABSTRACT Objective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index insert ignore into journalissuearticles values(BMI); on asthma control and pulmonary functions in asthmatic patients. Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included in the study between December 2016 and February 2017. At initial admission, demographic characteristics and pulmonary function tests insert ignore into journalissuearticles values(PFT); were recorded and laboratory tests including serum vitamin D, calcium, phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test insert ignore into journalissuearticles values(ACT); was performed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreased vitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT and PFT were repeated after therapy at third month in asthmatic patients. Results: There were totally 95 individuals; 76 females insert ignore into journalissuearticles values(80%); and 19 males insert ignore into journalissuearticles values(20%);, There were no significant difference between age, gender and demographic characteristics between asthmatics and control group. Smoking status and passive smoking rates were similar. There was no significant difference between daily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkaline phosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levels were low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled, while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation. There was a significant increase of ACT with respect to vitamin D replacement therapy insert ignore into journalissuearticles values(22.4 ± 2.7 vs 16 ± 5.4, p=0.001);. The mean BMI were high in both groups insert ignore into journalissuearticles values(≥30 kg/m²);. The mean ACT score was lower in obese asthmatics than in non-obese patients, but the difference was not significant insert ignore into journalissuearticles values(15.3 ± 5.4 vs. 17.5 ± 4.8, p= 0.1);. Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups insert ignore into journalissuearticles values(p = 0.744);. Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control and pulmonary functions but further multicenter, prospective studies with large number of cases are needed to evaluate the effect of vitamin D replacement therapy on these parameters. Keywords: Asthma; Vitamin D; Asthma Control Test insert ignore into journalissuearticles values(ACT);; Pulmonary Function Test insert ignore into journalissuearticles values(PFT);
Keywords : EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS, Astımlı, Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi