ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi

Authors : Alpaslan ÖZTÜRK, Mehmet Ali GÜL, Tuğba AĞBEKTAŞ, Cemile ZONTUL, Cem Hakan ÇİFTÇİ, Ayça TAŞ, Duygu YALINBAŞ YETER, Yavuz SİLİĞ

Pages : 52-57

View : 31 | Download : 24

Publication Date : 2023-09-15

Article Type : Research Paper

Abstract :ABSTRACT Objective: Age-related macular degeneration insert ignore into journalissuearticles values(AMD); is the most common cause of advanced visual loss in developed societies. ANXA3 contributes to tumor development by affecting cell signaling pathways, cell profiling, invasion, metastasis and cell apoptosis. The aim of this study was to compare serum ANXA3 levels in wet type and dry type macular degeneration patients with the control group and to investigate whether there is a significant difference between the groups. Material and Methods: A total of 78 patients insert ignore into journalissuearticles values(39 patients with wet AMD, 39 patients with dry AMD diagnosed at the same time period and 39 healthy controls without any previous diagnosis of macular degeneration); were enrolled in this study. ANXA3 levels were determined by enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA);. Results: Serum ANXA3 levels were found to be significantly higher in wet AMD than in the control group insert ignore into journalissuearticles values(p=0.005);. In addition, the difference between serum ANXA3 levels of wet and dry AMD patients was found to be significant. It was observed that there was a significant increase in wet type AMD patients insert ignore into journalissuearticles values(p=0.004);. However, no significant difference was found in ANXA3 levels in dry type AMD compared to the control group insert ignore into journalissuearticles values(p=0.444);. Conclusion: These findings suggest that ANXA3 protein may play an important role in age-related macular degeneration.
Keywords : ASSOCIATION OF SERUM ANNEXIN A3 ANXA3, LEVELS, WITH AGE RELATED MACULAR DEGENERATION, Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 Anxa3, Düzeylerinin İ