ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki

Authors : Mehmet Coşkun, Ismail Haskul, Salim Neşelioğlu, Özcan Erel

Pages : 40-43

View : 57 | Download : 74

Publication Date : 2024-03-15

Article Type : Research Paper

Abstract :Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasis in patients with type 2 diabetes. Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferative diabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy( PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/ TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded if they had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy, if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if they had a history of alcohol intake or smoking. Results: There was no significant difference between the groups in terms of age and gender (p=0.098 and p=0.16, respectively). No significant difference was observed between the groups with respect to disulfide levels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differences were found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; for TTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly different between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001) Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL were found to be lower as the retinopathy stage increased.
Keywords : ASSOCIATION BETWEEN THE STAGE OF DIABETIC, RETINOPATHY AND THIOL DISULFIDE HOMEOSTASIS, Diyabetik Retinopati Evresi ile Tiyol Disülfid Homeostazı Arasındaki İlişki