ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi

Authors : İbrahim Çaltekin, Ali Aygün, Mesut Tomakin, Ramiz Yazıcı, Güneş Seda Albayrak

Pages : 144-151

View : 47 | Download : 43

Publication Date : 2024-09-15

Article Type : Research Paper

Abstract :ABSTRACT Objective: We aimed to analyze the diagnostic value of new potential hemogram biomarkers in patients presenting to the emergency department with epileptic seizures. Material and Methods: Patients presenting with epileptic seizures to a tertiary hospital\'s emergency department between January 1, 2023, and January 1, 2024, were retrospectively reviewed. The patients were categorized into Group A (seizure patients) and Group B (healthy volunteers). Hemogram and biochemistry data from routine blood tests were examined. To predict seizure status, ROC analysis was performed to evaluate NLR, PLR and PNR. The area under the curve and cutoff values were calculated for each marker. Results: Our study examined two groups: seizure patients and the control group. The mean age of the seizure group was 50.31±1.83 years, and the mean age of the control group was 49.58±1.96 years (p>0.05). In the seizure group (n=116), 55.8% were male and 44.2% were female, whereas in the control group (n=104), 57.8% were male and 42.2% were female (p>0.05). WBC, neutrophil count, NLR, and PLR values were significantly higher in seizure patients compared to the control group (p<0.001, p<0.001, p<0.001, and p=0.035, respectively). PNR and lymphocyte values were significantly lower in seizure patients compared to the control group (p<0.001 and p=0.01, respectively). Conclusion: We found significant changes in NLR, PLR, and PNR values in patients with epileptic seizures. We believe that these biomarkers can assist clinicians in diagnosing seizures and distinguishing between seizures and pseudoseizures, especially in emergency departments.
Keywords : ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE, EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES, Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi

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