THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE STUDY Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma

Authors : Elem Yorulmaz, Duygu Geler Külcü

Pages : 215-220

View : 38 | Download : 27

Publication Date : 2024-12-15

Article Type : Research Paper

Abstract :Objective: This study aimed to determine the relationship between tosilizumab use and eosinophil counts in patients with rheumatoid arthritis. Material and Methods: Thirty five patients diagnosed with rheumatoid arthritis (RA) receiving either synthetic disease-modifying antirheumatic drugs (DMARDs) or tocilizumab treatment were included in this study. Patient age and disease duration, disease activity parameters and eosinophil values were recorded. Results: Comparing the eosinophil counts and percentages of the DMARD group with the Tocilizumab group, any statistically significant differences were found. There was no significant difference in eosinophil counts and percentages in the DMARD group in repeated measurements. However, in the Tocilizumab group, there was a significant difference in both parameters. Conclusion: A significant increase in eosinophil counts was observed in the group receiving tocilizumab therapy at the 1st month. Therefore, during treatment monitoring, especially in the early stages, attention should also be paid to eosinophil values.
Keywords : THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID, ARTHRITIS: A RETROSPECTIVE STUDY, Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma