Relationship between serum vaspin levels and the severity of coronary disease in non-diabetic patients with non-ST elevation myocardial infarction

Authors : Jihat BALI, Umut KARABULUT, Ahmet BÜYÜK, Cengiz ÇELİKER

Pages : 136-140

Doi:10.34087/cbusbed.1002213

View : 42 | Download : 43

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :Objectives: Vaspin is an adipocytokine, serine protease inhibitor, correlated to obesity, insülin sensitivity, diabetes mellitus, and coronary artery disease. The association between vaspin and coronary artery disease was shown in several studies. Whether this value is independent of diabetes in coronary artery disease patients is not known. Also, a study that shows the importance of vaspin in patients with Non-ST elevation myocardial infarction insert ignore into journalissuearticles values(NONSTEMI); is not conducted. This study aimed to investigate the relationship between serum vaspin levels and the severity of coronary artery disease, which is determined by the SYNTAX score, in nondiabetic patients with NONSTEMI Materials and Methods: A total of 165 nondiabetic patients with NONSTEMI were included in this cross-sectional study. Serum vaspin levels were measured by the ELISA method.SYNTAX scores were evaluated by two expert operators blinded to the angiography results. Patients were divided into three groups according to the SYNTAX score by the interquartile range method insert ignore into journalissuearticles values(group 1 with SS 22);. Results: Serum vaspin levels were found significantly different between three groups insert ignore into journalissuearticles values(p = 0,03); and significantly higher in group 1 than group 3 insert ignore into journalissuearticles values(p = 0,01);.No significant difference was found between group 1 and 2 also group 2 and 3 insert ignore into journalissuearticles values(p = 0, 52, p = 0.06 );.It was found to be a significant but weak negative correlation between the SYNTAX score and serum vaspin levels insert ignore into journalissuearticles values(r = -0,207, p = 0.008);. Conclusion: Vaspin negatively correlates to SYNTAX score and maybe a useful marker to show the severity of coronary disease in nondiabetic patients with NONSTEMI
Keywords : Vaspin, NONSTEMI, diyabetik olmayan, SYNTAX